HARVONI 12周用药方案（治疗中）
1）网名：Trish1 （初治、感染32年，8周治疗方案）
Age 51 年龄
Infected 1983 感染时间
GT 1a 分型
VL 5.1m 病毒量
Bx 2004 - Grd 1 Stg 1 肝损活检分级
Tx naive 初治
Started Harvoni 6/23/2015 (8 wks)（开始8周治疗时间）
4wk (during tx) - detected <15 （4周病毒量<15)
2）网名：nowhine （经治，12周 SVR3，注意： Q80K 阳性）
Gender: Male （男性）
Ht/Wt: 5'9 158 lbs. 58 years young （身高，体重，年龄）
GT（分型）: 1A and Q80K positive, （il28b分型)CT
VL（初始病毒量）: 7 mil
Previous Tx.（曾治疗情况和用药方案）
SOC INF/Rib Partial response Breakthrough （干扰素2联部分应答，病毒学突破）
Gilead Trail GS 9451 Protease, GS 5885 now ledipasvir, INF/Rib, Partial response Breakthrough
Started Harvoni on 3/24/15 （开始harvoni时间：15年3月24日）
4 week labs UNDETECTED, Liver funtion test all normal （4周未检测到，肝功全正常）
12 week labs about 3 weeks ago and STILL UNDETECTED （SVR3，治疗结束后3周病毒未检测到）
I have 12 more weeks and will post after next labs （将帖出12周检测结果（未更新））
3）网名：Sixfootfour （12周）
* Dx as Hep C early 2000（诊断时间）
* 分型：Geno 1b
* Stage 3-4 Fibrosis by Biopsy and FibroScan pre tx （肝纤3-4级）
* 初始病毒量：VL at start of TX > 6 mil
* ALT/AST High normal range at start of Tx
* 开始和结束时间 Started Harvoni 12 week course 3/6 - completion 5/29/2015
* Undetected at 7 weeks Tx 4/24/15
* ALT/AST Mid normal range at 7 week blood test
* Undetected at 10 weeks Tx 5/15/15
* Completed 12 weeks (84 pills) 6/28/15
* Waiting for SVR12（等待svr12检查数据）
4）网名：sabre （初治，12周）
Infected（感染)1980 / Diagnosed(确诊） 2008
分型：GT 1 / Treatment naive初治 /病毒量 VL 190,000
Biopsy活检 2008: stage 0 grade 1
Fibroscan肝弹 2015: F2 mild fibrosis
Chronic kidney disease (due to HCV) / Proteinuria
（HCV引起肾病，蛋白尿）
12 weeks Harvoni began on（12周harvoni治疗方案，开始时间） 03/28/2015
End of treatment（结束时间）: 06/19/2015
Labs on 06/17/2015: Undetected 未检测到
5）网名：sisterbland （12周 经治）
1987/88 Contracted HCV 1a 感染时间及分型
1997 Interferon/ribavirin 7 mo; relapser二联7个月复发
3/17/15 Harvoni started, 12 wks（开始治疗时间）
4/17/15 VL <15 IU/ML (Undetected)
6/11/15 Complete tx
6）网名：KC （12周）
Age 58 年龄
DX early 90's （90年代初确诊）
2/16/15 VL: 3,577,985 初始病毒量
AST: 81 ALT: 94 肝功
Fibrosis: F1 - F2 肝纤分级
3/18/15: Began Harvoni (12 week treatment)（开始12周治疗时间）
4/16/15: VL "UNDETECTED" <15（4周病毒量<15)
ALT: 29 AST: 30(肝功正常）
7）网名：S.Belle （12周、初治，肝纤3级，治疗2周alt asl由100降至正常，病毒检测不到）
Genotype 1 分型
Infected in early （感染）1990's Diagnosed in （确诊）2008
No previous treatment 初治
Fibrosure score F3 肝纤分级
Viral Load 94,000 初始病毒量
ALT 117 AST 115 初始肝功
Started Harvoni on July 14, 2015 (12 weeks)（开始12周治疗日期：15年7月14日）
Two weeks into Harvoni blood test results:
ALT 13 AST 21
Viral Load = UNDETECTED !!!
（治疗2周肝功检查正常，病毒量未检测到）
8）网名：Bree （经治，12周）
Dx 1997 Geno 1a（确诊时间：1997，分型：1a）
2002-2003 PEG Intron/riba (for 48 wks) - relapsed
（2002-2003年，干扰素二联，复发）
Viral Load: 13M - Log 7.1（病毒量）
Current Fibrosure Score F1-2（肝纤分级：F1-F2）
Started Harvoni (12 weeks) on July 6, 2015
（harvoni(12周方案），开始时间2015年7月6日）

HARVONI 8周，停药后复发，***注意尽量选12周
Karen1124 （8周 复发）
Geno 1a
VL 2 million
DX May 1 2014
Bio June 5 2014
moderate fibrosis
Start Harvoni 2/5/2015
EOT 4/1/2015
7/22/2014 alt 186 12/30 64 3/5/15 39
7/22/14 ast 114 12/30. 41 3/5/15 27
Don't know how I got hep C in my 20s I did snort coke a few times.
3/5/15 undetected
4/2/15 less than 15 VL ferrin levels normal
4/9/15 undetected!!
6/24/15 relapse VL 424,000

一个代偿期肝硬化SVR后逆转案例，详情可以google得到，并可以在论坛与他/她回帖交流
2012年前肝硬度检测：肝纤F3级，诊断：代偿期肝硬化
SVR3年后，
2015年：肝纤F0-F1级，B超：肝回声正常、肝表面光滑，肝脏正常
网名：ppmguy
i have been SVR since mid 2012. my last biopsy was 1999. I was stage 3 at that time. my hepatologist did a fibroscan today(3-4-15).
F1
my overall score is 4.5 kpa. from compensated cirrhosis to F1-FO, NORMAL.
i had cirrhosis in 2012 when i cleared the virus.
on march 5th, 2015 i had a fibroscan
result was 4.5 kpa = f 0 to f 1 NORMAL
yesterday i had a ultrasound to cross referrence the fibroscan.
result was; echogenicity was normal
liver surface is smooth
liver appears normal
my hepatologist wasnt surprised. she stated that if the liver is cirrhotic,
but fully functioning, the liver can heal itself.

一个肝硬化经治疗至非肝硬化案例：
治疗3年前：B超回声增粗，诊断：肝硬化。
3年后：B超诊断：无肝硬化表征
还提到有两个病人病毒转阴后肝硬度检测肝纤级别降低1-2个级别
网名：Dee1956
在一个回帖中说：
Hello! I think it all depends on how far along the cirhosis is and it depends on the person
I was dx with the possible transitioning to cirrhosis due to wisps of collagen seen in my biopsy. My ultrasound showed a rough echotexture.
It has been 3 years since I finished tx. In June I had an ultrasound that for the first time said smooth texture, no sign of cirrhosis. I was shocked as I assumed that I would always have the rough echotexture that had been seen since 2008
There have been two members who have come back several years later to tell us that the stage of scarring and fibrosis had reduced a level or two since they finished treating. (Andiamo1 and JimJim)
I know another person who had a high meld score who treated and is now cured and his/her meld score has reduced quite a bit.
I hope the same happens for you.
My doctor explained that once the virus is not attacking your body, healing can occur. Of course that includes eating well, not drinking etc.
Take Care, Dee

一个失代偿期肝硬化案例：
发帖时SVR4，其他回帖中显示：他/她已SVR7，但临床症状仍未改善：
轻度腹水
血小板：41
胆红素高
应该还有门静脉高压
网名：FoxTheRed 2015年8月12日
Today is 4th week after end of therapy. And HCV still undetected. But bilirubin is highj enough ( 2 mg/dL ) and PLT count is low. And mild ascite is in place ( mild ascite without diuretics and no ascite on diuretics )
As i know, in US and EU modern therapy become available much before other countries. So i has a question -
Is here somebody, who got significant improvement in liver functions and portal hypertension after SVR ?
Result from my last blood test
INR - 1.35
total bilirubin - 2.3 mg/dl
albumine - 33
ALT,AST,AlkP,GGT,AFP - norm
PLT - 41

一个肝硬化用药12周复发案例，注意5周病毒检测到，按happywanny经验，应该加治疗周期，即失败在病毒转阴慢、治疗用药时间短，后续治疗方案：医生在向保险公司申请24周harvoni方案，或加利巴韦林）
网名：tmf2 （肝硬化，12周harvoni）
Finished Harvoni 7/7（2015年7月7日完成治疗）,
5th week in still detected （5周仍检测到**所以happy注重12周是对的，应该加疗程）
8th week undetected （8周检测不到）
**three weeks post EOT detected. （治疗结束后3周检测到病毒）
AST 156 ALT 302 up from AST 37 ALT 40. （复发后转氨酶上升）
I am stage 4 Cirrhosis with a Child score A （肝硬化分级：CTP A级）
treatment naive. （初治）
Treatment was 12 weeks Harvoni. （12周 Harvoni方案）
My hopes are dashed. My doctor is attempting to get me approved from my Insurance for 24 weeks of Harvoni possibly with Ribavirin. Is this the best course of action and if they do not approve should I try for the Viekera Pak ? Depressed worried and confused.（医生向保险公司争取Harvoni 24周或加利巴韦林方案）